A 50mph speed limit will be imposed between junction 37 and 38 of the M1 while work is carried out to fit a new central reservation.
The Highways Agency will replace the existing steel barrier with concrete to reduce the risk of vehicles involved in accidents from crossing sides of the motorway.
Work will start on October 15 and is due to last until December 21. Three narrowed lanes will be in operation during the day but there may be lane closures overnight.
Project manager, Tim Calvert, said disruption would be kept to a minimum and the new barrier would increase safety on the M1.
“During the work a 50mph speed limit will be in place to ensure the safety of road users and our work force. We advise road users to plan their journeys to avoid delays.
"Safety is our top priority and for the safety of road users and road workers we encourage all drivers to drive carefully past the works, keeping within the speed limit, and concentrating on the road ahead.”